Guides
Everything you need to know about building a PC for local AI. From understanding VRAM to buying used GPUs smart.
How Much VRAM Do You Actually Need?
EssentialThe definitive guide to VRAM requirements for every workload — local LLMs, image gen, video gen, scientific computing, and code models. Real data, real numbers, no fluff.
Best GPU for AlphaFold & Protein Structure Prediction
ScientificThe bioinformatician's GPU buying guide. AlphaFold, ESMFold, RFdiffusion, scGPT — real VRAM requirements, GPU compatibility matrix, and setup instructions.
NVIDIA vs AMD for AI Workloads
ComparisonShould you buy NVIDIA or AMD for AI? An honest comparison of CUDA vs ROCm, real-world compatibility tables, and which to buy for every use case.
What is Quantization?
BeginnerA beginner's guide to Q4, Q8, and FP16. Learn how quantization affects model quality, speed, and VRAM usage — and which precision to use for your GPU.
Best VRAM Per Dollar
RankingsEvery GPU ranked by cost efficiency for AI. Find out which cards give you the most VRAM per dollar — the most important metric for budget AI builders.
Used GPU Buying Guide
BuyingThe best-value AI GPUs in 2026 are used. How to buy safely, what to check, mining history risks, and our top picks ranked by VRAM per dollar.